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MITOCHONDRIA AND CELL DEATH Besides their fundamental role in energy generation, mitochondria also play a strategic role in the regulation of cell death, including apoptosis (caspase-dependent and independent) and necrosis

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Glutamine activates mTORC1 through a special mechanism that requires ADP ribosylation factor 1 and is independent of Rag GTPase to stimulate the lysosomal localization of mTORC1 and to exert its physiological functions, such as controlling cell growth, metabolism and autophagy (35)

In response to carboplatin, targeting MUC1-C helped to overcome DNA damage resistance in the treatment of TNBC (227)